Ozone-induced alterations of lamellar body lipid and protein during alveolar injury and repair

Alveolar Type II cells in the rat respond to severe, acute ozone injury (3 ppm ozone for eight hours) by increasing their intracellular pool of surfactant; however, the newly stored surfactant is abnormal in composition. Lamellar bodies isolated between 24 and 96 hours after ozone exposure contained significantly more cholesterol in relation to phosphatidylcholine than did controls. By contrast, the cholesterol content of surfactant isolated from alveolar lavage remained unchanged throughout an 8-day post-ozone period. The total protein content of lamellar bodies in relation to phosphatidylcholine was significantly decreased at 24 and 48 hours post-ozone. Analysis of lamellar body proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that the amount of a 14 kDa proteolipid was greatly reduced at the end of the eight-hour ozone exposure and remained low for at least 48 hours. This proteolipid appeared to be a specific lamellar body component since it was not detected in extracellular surfactant. The findings indicate that oxidative alveolar stress initiates characteristic alterations in both lipid and protein constituents of stored surfactant, without perturbation in the composition of extracellular surfactant.     

Fracture behavior of core‐shell rubber–modified clay‐epoxy nanocomposites

Morphology and fracture mechanisms in two nanoclay‐filled epoxy systems were investigated using both microscopy and spectroscopy tools. Clay exfoliation was achieved using a series of sample preparation steps, and confirmed using wide angle X‐ray diffraction (XRD) and transmission electron microscopy (TEM) techniques. Significant improvement in modulus was obtained when clay exfoliation was achieved. Incorporation of core‐shell rubber (CSR) in both caly‐filled epoxy systems leads to greatly enhanced fracture toughness. Optical microscopy and TEM observations of the CSR‐modified nanocomposites suggest that CSR cavitation. shear yielding of the matrix, clay layer delamination. CSR bridging, crack bifurcation. and crack deflection are among the operative toughening mechanisms observed, depending on the nature of the epoxy matrix utilized.     

Value not virtual ‐ one library's response to the virtual campus

The purpose statement of Deakin University Library is ‘We help people learn.’ This applies equally to on or off‐campus students, which has meant that the Library has strived to provide innovative resources and services to break down the barriers of geography and time experienced by our remote students. With the advances in information and communication technologies, Deakin University Library has been able to capitalise on these developments to deliver electronic services to both on and off‐campus students, thus complementing the valuable services provided by the Library team. While the services provided through the virtual or digital library are a great leap forward, providing access to a wide range of resources and services 24 hours per day x 7 days per week, these services must be seen in conjunction with the professional assistance provided by librarians. Deakin University Library's success is in its customer focus and the value added digital services available through the virtual campus.     

Understanding post‐adoption IS usage stages: an empirical assessment of self‐service information systems

Organisations have invested in self‐service information systems (IS) to provide a direct interface for service delivery. Enriching the usage of these systems can provide organisations with immense benefits. However, limited research has been directed towards understanding post‐adoption IS usage behaviour in general and specifically in the context of self‐service IS. This study proposes post‐adoption IS usage behaviour as a broader concept constituting feature level usage of IS, integration of IS in the work system and exploration of new uses of IS. We evaluate how the new conceptualisation can be used to classify users at different stages of self‐service IS usage. Further, we examine user perceptions that differentiate among the users situated at different self‐service IS usage stages. Data were collected in the context of a self‐service Web‐based IS to validate the post‐adoption IS usage constructs and to examine the proposed thesis. The newly developed conceptual structure and measures for post‐adoption IS usage behaviour exhibit strong psychometric properties. The analysis shows three distinct post‐adoption IS usage stages and highlights that usefulness, user‐initiated learning, ease of use, satisfaction and voluntariness of use differentiate users at the different stages of post‐adoption IS usage. The results show that these variables aggregate into value confirmation and learning orientation as two higher‐level concepts. Further, we evaluate the predictive efficacy of the research model in classifying users into different post‐adoption self‐service IS usage stages. Implications are drawn for future research.     

Web proxy cache replacement scheme based on back-propagation neural network

Web proxy caches are used to reduce the strain of contemporary web traffic on web servers and network bandwidth providers. In this research, a novel approach to web proxy cache replacement which utilizes neural networks for replacement decisions is developed and analyzed. Neural networks are trained to classify cacheable objects from real world data sets using information known to be important in web proxy caching, such as frequency and recency. Correct classification ratios between 0.85 and 0.88 are obtained both for data used for training and data not used for training. Our approach is compared with Least Recently Used (LRU), Least Frequently Used (LFU) and the optimal case which always rates an object with the number of future requests. Performance is evaluated in simulation for various neural network structures and cache conditions. The final neural networks achieve hit rates that are 86.60% of the optimal in the worst case and 100% of the optimal in the best case. Byte-hit rates are 93.36% of the optimal in the worst case and 99.92% of the optimal in the best case. We examine the input-to-output mappings of individual neural networks and analyze the resulting caching strategy with respect to specific cache conditions.     

Design and dynamics of an innovative micro gyroscope against coupling effects

This paper presents an innovative micro gyroscope design. The proposed tri-axis gyroscope possesses the capability of detecting three-dimensional angular motions. The motion of each sensing element is, by elaborate mechanical design, restricted to move in orthogonal direction to each other such that the measurements by high-resolution capacitors with signal processing circuits are decoupled and precisely represent, to some extent, angular velocity components in three axes. The drive electrode comb is used to constantly vibrate the proof mass in tangential direction by sinusoidal voltage. The signal bandwidth is increased by distributed translational proof masses, placed ninety degree apart from each other. Each individual proof mass is designed to move solely in radial direction so that superior mode matching can be achieved. In order to ensure better repeatability and more reliability, the suspension flexures and damping effects are studied such that stress of the proposed micro gyroscope is reduced but the span of angular displacements is increased. Owing to the complicated geometry of the suspension flexures, finite element method (FEM) is employed to obtain more exact stiffness values and compared with theoretical analysis. The dynamic model of the proposed gyroscope is established to include non-linear terms and embedded mechanical constraints. The entire micro device can be produced merely by surface fabrication such that the mass production cost can be considered at the design stage, while the resolution, bandwidth and decoupling capability of tri-axis detection are enhanced.